ISDINCEUTICS

ISDINCEUTICS Retinal Advanced

Dual-phase night serum with retinaldehyde

4.7

$185

Retinal Advanced is a youth-boosting night serum that helps visibly reduce wrinkles and fine lines. Designed with an innovative dual-phase technology, it combines the power of retinaldehyde, melatonin and bakuchiol with Soothing Complex at the moment of application. Add it gradually into your PM routine to unveil smooth, rejuvenated skin after 4 weeks.

50 ml
All skin types
Non-comedogenic, mineral oil-free, not recommended for use during pregnancy
Fines lines and wrinkles, loss of firmness and elasticity, dullness
Retinaldehyde, melatonin, bakuchiol, Soothing Complex

BENEFITS

Make way for dreamy skin

Rejuvenate your skin while dreaming with our dual-phase night serum, designed to combat wrinkles and boost skin renewal.

Dual-phase, dual action

Retinal Advanced powerfully targets signs of skin aging while gently soothing your skin, promoting youthful radiance.

Rejuvenates

Helps reduce wrinkles and fine lines, smoothing the skin for a younger-looking complexion.

Renews

Promotes gentle skin surface turnover, helping improve the skin’s overall texture and appearance.

Soothes

Hydrates and calms the skin, minimizing the sensation of dryness.

CLINICAL RESULTS

Results:

-43%

Wrinkles after 4 weeks¹

97%

Noted a reduction in wrinkles and fine lines²

97%

Noted no discomfort²

91%

Noted firmer skin³

¹Evaluation of effectiveness in 34 women (41-70 years) with all skin types with moderate to severe photodamage during 84 days. Data on file. ISDIN Corp., 2024. Morristown, NJ. ²Usage test to evaluate the effectiveness and safety by dermatological evaluation and subjective questionnaires of Retinal Advanced in 34 subjects (41-70 years old) with all skin types including sensitive skin for 12 weeks, applied once a day. Data on file. ISDIN Corp., Morristown, NJ, 2024. ³Usage test to evaluate the effectiveness and safety by dermatological evaluation and subjective questionnaires of Retinal Advanced in 34 subjects (41-70 years old) with all skin types including sensitive skin for 4 weeks, applied once a day. Data on file. ISDIN Corp., Morristown, NJ, 2024.

KEY INGREDIENTS

Powerful ingredients combined in two unique phases

Retinal Advanced has a unique formulation that features both rejuvenating and soothing ingredients.

Retinaldehyde

A derivative of vitamin A, it supports collagen production and skin renewal while also helping unify complexion.

Melatonin

When applied topically, it acts as an indirect antioxidant, stimulating natural defenses against harmful free radicals

Bakuchiol

Of natural origin, it demonstrates retinol-like properties, gently helping restore elasticity and firmness.

Soothing Complex

Ultra-soothing ingredients, including niacinamide, work together to hydrate, calm, and revitalize the skin.

HOW TO USE

Your youth-boosting night serum

Apply at night onto clean and dry skin. Press the pump twice to dispense the right amount into the palm of your hand, mix well, and apply. Massage serum onto your face and neck, avoiding the eye area. The next morning, make sure to always apply a broad spectrum sunscreen, such as Eryfotona Actinica or Eryfotona Ageless. If it’s your first time using a retinoid, we recommend being mindful of the retinization period. Start by applying it three nights a week. In the second week, apply it four nights. Then, if you haven’t noticed any discomfort in the third week, feel free to up application to seven nights a week.

Dispense

Press two pumps into the palm of your hand and mix well.

Apply

Apply onto clean, dry skin, massaging until completely absorbed and avoiding the eye area.

Protect

Protect your skin with broad spectrum sunscreen the next morning, reapplying during the day as directed on the label.

Add Retinal Advanced to your routine

Include Retinal Advanced in your nighttime skincare routine for smooth, rejuvenated skin.

Cleanser

Rinse away impurities with your go-to cleanser.

Eye cream

Smooth your eye cream onto the under-eye area.

Serum

Boost your routine with Retinal Advanced.

Face cream

Apply a hydrating face cream to lock in moisture.

Sun protection

Protect your skin with broad spectrum sunscreen the following morning.

FREQUENTLY ASKED QUESTIONS

Is Retinal Advanced suitable for sensitive skin?

Yes! It’s suitable for all skin types. Retinal Advanced has been clinically tested on a wide range of skin types, including sensitive skin.

Can I use Retinal Advanced day and night?

The use of retinoids can make the skin more sensitive to external factors, meaning that the effect of sun exposure can be more intense. Because of this, we recommend using it at night, followed by a broad spectrum sunscreen in the morning, reapplying during the day as directed on the label.

What is retinization?

Retinization is the time it may take your skin to adapt to retinoids (like retinaldehyde and retinol). When introducing Retinal Advanced into your routine, it’s recommended to start slow: use it three nights at week at first, then four nights the following week, going up to seven nights in the third week. If you notice prolonged discomfort, limit use and if discomfort persists, consult your dermatologist.

Why is it a dual-phase texture?

Its dual-phase formula separates the oil phase (rejuvenating ingredients) from the aqueous phase (soothing ingredients). Phases are separated in the package to help preserve the effectiveness and stability of the formula. They are combined at the moment of application.

What’s the difference between retinal and retinol?

While both are retinoids, retinal (or retinaldehyde) is closer to retinoic acid (the prescription form) than retinol, meaning it has a higher activity.